The etiologic agent for infectious mononucleosis is epsteinbarr virus, although a. Pediatric infectious mononucleosis childrens national hospital. In consideration of payment of the applicable subscription fee, the aap is willing to. Whereas most ebv infections of infants and children are. Infectious mononucleosis is either caused by the epsteinbarr virus ebv or the cytomegalovirus, both of whom are members of the herpes simplex virus family. In latin american countries, there are little information pertaining to the clinical manifestations and complications of this disease. Mononucleosis diagnostico y tratamiento mayo clinic. Between 1976 and 1982, 1 children aged 6 months to 16 years with documented epsteinbarr virusinduced infectious mononucleosis were studied prospectively, and in most instances serially.
The present study aims at an assessment of hepatosplenomegaly in infectious mononucleosis im. A case of severe encephalitis due to infectious mononucleosis is reported. Infectious mononucleosis american academy of pediatrics. Epsteinbarr virus, mononucleosis, pediatric infections. In 29 patients admitted to the ent department with im, based on the typical clinical and laboratory findings, including a positive mononucleosis test in most cases, the size of the liver and spleen was estimated by ultrasonic scanning on days 1, 3, 5, 10, 20, 30, 90 and 120 after admission. In 1885, the renowned russian pediatrician nil filatov reported an infectious process he. Im is a clinical syndrome caused by epsteinbarr virus. Infectious mononucleosis is a clinical entity characterized by sore throat, cervical lymph node enlargement, fatigue, and fever most often seen in adolescents and young adults and lasting several weeks. Complete blood count cbc may be done to help confirm the diagnosis of mono and rule out other infections or complications of mono. Pdf clinical and laboratory characteristics of infectious. Infectious mononucleosis is a clinical entity characterized by sore throat, cervical lymph node enlargement, fatigue, and fever most often seen in adolescents and. Epsteinbarr virus infectious mononucleosis in children ii. Apresenta distribuicao universal e pode ocorrer em qualquer faixa etaria.
After the fever is gone, the virus is still carried in the saliva for up to 6 months, but in small amounts. Infectious mononucleosis im is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy. Epsteinbarr virus infections, coinfection, infectious mononucleosis, pediatrics. Levels of antibodies specific to epsteinbarr virus ebv during infectious mononucleosis and convalescence. Mono is usually a mild illness that goes away without treatment after several weeks. Mononucleosis tests including the monospot test and ebv antibody test are blood tests. Infectious mononucleosis im, mono, also known as glandular fever, is an infection usually. Infectious mononucleosis infectious diseases msd manual. Infectious mononucleosis is caused by epsteinbarr virus ebv, human herpesvirus type 4 and is characterized by fatigue, fever, pharyngitis, and. The classic physical findings of infectious mononucleosis include. Louis university school of medicine and cardinal glennon childrens hospital, st.
Few studies of pediatric epsteinbarr virus ebvassociated infectious mononucleosis im have been conducted in korea. Infectious mononucleosis, also known as mononucleosis, mono, or glandular fever, is characterized by swollen lymph glands and chronic fatigue. Pediatric infectious mononucleosis childrens national. Infectious mononucleosis forest hills pediatric associates. Children with infectious mononucleosis, in particular the very young, tended to have more rashes. Mononucleosis is an incredibly variable disease, says dr. A mononucleose infecciosa mi e uma doenca viral, contagiosa, causada pelo virus epsteinbarr ebv. Infectious mononucleosis im is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy 1. Jul 20, 2012 background infectious mononucleosis im or mononucleosis syndrome is caused by an acute infection of epsteinbarr virus. Clinical features of epsteinbarr virusassociated infectious. Epsteinbarr virus ebv infectious mononucleosis mono.
The etiologic agent for infectious mononucleosis is epsteinbarr virus. Infectious mononucleosis as a potential risk to the dentist. Junker did not disclose any financial relationships relevant to this article. It is possible for the monospot test to come back negative early in the course of the infections false negative. There a re no obvious a nnua l cycles or seasona l ch anges in incidence, and there is no apparent predi sposition. Mononucleosis mono is an infectious disease caused most often by the epsteinbarr virus ebv. The most common manifestation of primary infection with this organism is acute infectious mononucleosis, a selflimited clinical syndrome that most frequently affects adolescents and young adults. Epsteinbarr virus infectious mononucleosis american family.
Infectious mononucleosis and the epsteinbarr virus jama. Infectious mononucleosis im, mono, also known as glandular fever, is an infection usually caused by the epsteinbarr virus ebv. Special announcement apr, 2020 as a precaution, all patients and visitors coming to boys town hospital and clinics will be screened upon arrival, boys town hospital has postponed nonurgent, non. The term glandular fever was first used in 1889 by german physicians and was termed drusenfieber. Overall, mononucleosis is only slightly contagious from contacts. In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and tiredness. Whereas most ebv infections of infants and children are asymptomatic or have nonspecific symptoms, infections of adolescents and. The diagnosis of infectious mononucleosis was confirmed by a heterophile antibody titer of 1. An eight year old white boy developed meningeal signs, intermittent coma, opisthotonos, extensor spasms, mild papilledema and hyperpyrexia two weeks after the onset of a sore throat and cervical lymphadenopathy.
Pediatric epstein barr virus carriers with or without tonsillar enlargement may. Mononucleosischild care and schools patient education. A 16yearold, previously healthy girl presents with a severalday history of fever, sore throat, and malaise. Children with infectious mononucleosis, in particular the very young, tended to have more rashes, significant neutropenia, abdominal pain older children only, and possibly hepatosplenomegaly. Oct 01, 2004 infectious mononucleosis should be suspected in patients 10 to 30 years of age who present with sore throat and significant fatigue, palatal petechiae, posterior cervical or auricular adenopathy. Professor, department of pediatrics, division of infectious disease, st.
Mononucleosis infecciosa infectious mononucleosis dra. The american academy of pediatrics aap hosts the website and related materials on its servers and makes them available via the internet to subscribers for noncommercial research and education purposes and for use in providing healthcare services. Even after the early effects disappear, fatigue and weakness may linger for several weeks or more. Pdf infectious mononucleosis im or mononucleosis syndrome is. Clinical and laboratory characteristics of infectious. An unexpected finding was the large number of young children, less than 4 years old, with this disease. Sep 20, 2018 infectious mononucleosis was first described by sprunt and evans in the bulletin of the johns hopkins hospital in 1920. This is done in the light of recent knowledge concerning the epsteinbarr virus as well as previous studies employing the traditional diagnostic criteria of heterophil positivity, the classical clinical syndromes, and. Pediatric mononucleosis and epsteinbarr virus infection. Clinical and laboratory characteristics of infectious mononucleosis. Ebna denotes ebv nuclear antigen, and vca viral capsid antigens. Epsteinbarr virus infectious mononucleosis in children.
Most people are infected by the virus as children, when the disease produces few or no symptoms. Mononucleosis infecciosa en pediatria diego gerardo prado molina, md1 maria camila posada munoz, md2 shabelly andrea tabares. It was initially described as drusenfieber or glandular fever in 1889, but the term infectious mononucleosis was later used in 1920 to describe six college students with a febrile illness characterized by absolute lymphocytosis and atypical mononuclear cells in. They described the clinical characteristics of epsteinbarr virus ebv infectious mononucleosis. For this reason, the purpose of this work was to describe the clinical and laboratory characteristics of infection by epsteinbarr virus in. Epsteinbarr virus infectious mononucleosis american. Assistant professor, department of pediatrics, division of emergency medicine. Mar 22, 2021 epsteinbarr virus ebv, or human herpesvirus 4, is a gammaherpesvirus that infects more than 95% of the worlds population.
It was initially described as drusenfieber or glandular fever in 1889, but the term infectious mononucleosis was later used in 1920 to describe six college students with a febrile illness characterized by absolute lymphocytosis and atypical mononuclear cells in the blood 2,3. Pdf epsteinbarr virus and infectious mononucleosis. Report a possible correlation between necrotizing ulcerative. Fisher, a member of the american academy of pediatrics committee on infectious diseases. Pablo lara vega summary infectious mononucleosis im is a clinical syndrome caused by epsteinbarr virus ebv. Hepatosplenomegaly in infectious mononucleosis, assessed by. She appears very tired and has a temperature of 39c.
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